Novel Therapeutics to Treat Adolescent Drug Abuse

Adolescent vulnerability to methamphetamine: Dose-related escalation of self-administration and cue extinction deficits

SJ Luikinga, HB Madsen, IC Zbukvic, CJ Perry, AJ Lawrence, JH Kim

2025-04-01

Adolescence is the most vulnerable period for developing substance use disorders, with adolescents relapsing more compared to adul..

Genes and Cognitive Deficits in Adolescent-Onset Methamphetamine Use Disorder: Preliminary Evidence From a Cross-Sectional Study

Alexandre Guerin, Yvonne Bonomo, Kiymet Bozaoglu, Brian Dean, Andrew Lawrence, Michael Berk, Susan Rossell, Jee Hyun Kim

2021-05-01

Chronic voluntary alcohol consumption causes persistent cognitive deficits and cortical cell loss in a rodent model

AJ Charlton, C May, SJ Luikinga, EL Burrows, J Hyun Kim, AJ Lawrence, CJ Perry

2019-12-01

Chronic alcohol use is associated with cognitive decline that impedes behavioral change during rehabilitation. Despite this, addic..

Extinction of conditioned cues attenuates incubation of cocaine craving in adolescent and adult rats

HB Madsen, IC Zbukvic, SJ Luikinga, AJ Lawrence, JH Kim

2017-09-01

Relapse to drug use is often precipitated by exposure to drug associated cues that evoke craving. Cue-induced drug craving has bee..

Aripiprazole facilitates extinction of conditioned fear in adolescent rats

DE Ganella, L Lee-Kardashyan, SJ Luikinga, DLD Nguyen, HB Madsen, IC Zbukvic, R Coulthard, AJ Lawrence, JH Kim

2017-05-09

Anxiety disorders are the most common type of mental disorder during adolescence, which is at least partly due to the resistance t..

Prefrontal dopaminergic mechanisms of extinction in adolescence compared to adulthood in rats

IC Zbukvic, CHJ Park, DE Ganella, AJ Lawrence, JH Kim

2017-02-22

Adolescents with anxiety disorders attain poorer outcomes following extinction-based treatment compared to adults. Extinction defi..

Knockdown of corticotropin-releasing factor 1 receptors in the ventral tegmental area enhances conditioned fear

NA Chen, DE Ganella, RAD Bathgate, A Chen, AJ Lawrence, JH Kim

2016-09-01

The neuropeptide corticotropin-releasing factor (CRF) coordinates the physiological and behavioural responses to stress. CRF recep..

Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats

IC Zbukvic, DE Ganella, CJ Perry, HB Madsen, CR Bye, AJ Lawrence, JH Kim

2016-06-01

Adolescent drug users display resistance to treatment such as cue exposure therapy (CET), as well as increased liability to relaps..